Patients had serious, sometimes fatal, pneumonia and were admitted to the designated hospital in Wuhan, China, by Jan 2, 2020. Global Health Trials is a free and open access collaborative programme to support clinical trials in developing countries. ICU=intensive care unit. Clinical presentations greatly resemble SARS-CoV. These features of 2019-nCoV infection bear some resemblance to SARS-CoV and MERS-CoV infections.A major outbreak of severe acute respiratory syndrome in Hong Kong.Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study.Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study.The pathophysiology of unusually high pathogenicity for SARS-CoV or MERS-CoV has not been completely understood. Registration is Free!By creating an account I agree to PoweredTemplate’s The research team will provide an email address for communication once the data are approved to be shared with others. NA=not applicable. The Aim….

These features of 2019-nCoV infection bear some resemblance to SARS-CoV and MERS-CoV infections. Similarities of clinical features between 2019-nCoV and previous betacoronavirus infections have been noted. Second, with the limited number of cases, it is difficult to assess host risk factors for disease severity and mortality with multivariable-adjusted methods. Further studies in outpatient, primary care, or community settings are needed to get a full picture of the spectrum of clinical severity. To add products in favorites you must first register or login.

Inclusive Features For You. We acknowledge all health-care workers involved in the diagnosis and treatment of patients in Wuhan; we thank the Chinese National Health Commission for coordinating data collection for patients with 2019-nCoV infection; we thank WHO and the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) for sharing data collection templates publicly on the website; and we thank Prof Chen Wang and Prof George F Gao for guidance in study design and interpretation of results.A novel coronavirus associated with severe acute respiratory syndrome.Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.Identification of a novel coronavirus in patients with severe acute respiratory syndrome.Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group.Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003.Middle East respiratory syndrome coronavirus (MERS-CoV).First travel-related case of 2019 novel coronavirus detected in United States.A novel coronavirus genome identified in a cluster of pneumonia cases — Wuhan, China 2019−2020.Relationship between the presence of hypoxemia and the inflammatory response measured by C-reactive protein in bacteremic pneumococcal pneumonia.KDIGO clinical practice guideline for acute kidney injury.Association between cardiac injury and mortality in hospitalized patients infected with avian influenza A (H7N9) virus.Coronaviruses post-SARS: update on replication and pathogenesis.A major outbreak of severe acute respiratory syndrome in Hong Kong.Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study.Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile.Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS.Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside?.Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques.Corticosteroids as adjunctive therapy in the treatment of influenza.Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome.Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected.Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings.Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial.Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting. In this cohort, most patients presented with fever, dry cough, dyspnoea, and bilateral ground-glass opacities on chest CT scans. Participant data without names and identifiers will be made available after approval from the corresponding author and National Health Commission. Common complications included ARDS (12 [29%] of 41 patients), followed by RNAaemia (six [15%] patients), acute cardiac injury (five [12%] patients), and secondary infection (four [10%] patients; Data are median (IQR) or n (%).

The clinical symptoms and physical examination findings in patients with this syndrome are recognised widely and various treatments exist, including non-surgical and surgical options. Contact The time between hospital admission and ARDS was as short as 2 days. At this stage, the mortality rate is high for 2019-nCoV, because six (15%) of 41 patients in this cohort died.The number of deaths is rising quickly.

All rights reserved. ECMO=extracorporeal membrane oxygenation.As of Jan 22, 2020, 28 (68%) of 41 patients have been discharged and six (15%) patients have died.

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