Berkyurek, A. C. et al. The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. & Wang, Z. Readout of epigenetic modifications. Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Deleris, A. et al.

S.E.J. The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. & Liu, Y. Convergent transcription induces dynamic DNA methylation at disiRNA loci.

Learn Mem. Rigal, M., Kevei, Z., Pelissier, T. & Mathieu, O. DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns. Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Lewis, Z. In DNA methylation, a methyl group is added either to cytosine or adenine nucleotide of the DN… (a) Pre-training intra-CA1 infusions of NaB do not affect an animal’s ability to perceive and respond to footshock during training. Pontier, D. et al. Deregulation of histones modification are found to be responsible for deregulated gene expression and hence associated with neurological and psychological disorders, such as Substance Abuse and Mental Health Services Administration, Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-48, HHS Publication No. Elsevier Science Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. The members of this family have multiple functions, not only with activating and silencing genes, but also affect development and have implications in human diseases.There are other proteins that have acetylating abilities but differ in structure to the previously mentioned families. Epub 2013 Jan 17.Front Aging Neurosci. A. Leung, D. C. & Lorincz, M. C. Silencing of endogenous retroviruses: when and why do histone marks predominate? Rajakumara, E. et al. & Bestor, T. H. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Shinkai, Y. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Pikaard, C. S., Haag, J. R., Ream, T. & Wierzbicki, A. T. Roles of RNA polymerase IV in gene silencing. Redundant mechanisms to form silent chromatin at pericentromeric regions rely on BEND3 and DNA methylation. Gelato, K. A. et al.

Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger. & Garrett, P. W. DNA sequence duplications trigger gene inactivation in Selker, E. U. Premeiotic instability of repeated sequences in Cambareri, E. B., Jensen, B. C., Schabtach, E. & Selker, E. U. Repeat-induced G-C to A-T mutations in Belden, W. J., Lewis, Z. Glucose availability affects the intracellular pool of acetyl-CoA, a central metabolic intermediate that is also the acetyl donor in histone acetylation. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. While a single methylation of this region allows for the genes bound to remain transcriptionally active,Due to the fact that histone methylation regulates much of what genes become transcribed, even slight changes to the methylation patterns can have dire effects on the organism. Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Tran, R. K. et al.

is an investigator of the Howard Hughes Medical Institute.Jiamu Du and Lianna M. Johnson: These authors contributed equally to this work.Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, ChinaHoward Hughes Medical Institute and Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, 90095, California, USAStructural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, 10065, New York, USAYou can also search for this author in Espada, J. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Wang, C. et al. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Jin, B. et al.

Please enable it to take advantage of the complete set of features! Leung, D. C. et al. DNMT3L connects unmethylated lysine 4 of histone H3 to Edwards, J. R. et al. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. The process is aided by factors known as Histone Acetyltransferases (HATs). Examples are telomeric repeats, transposable elements, and centromeric repeats.One of the two X chromosomes in females is inactivated to prevent overexpression of X gene products in females compared to males.

Gopalakrishnan, S., Sullivan, B. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. A clear understanding is developing concerning the importance of epigenetic-related molecular mechanisms in transcription-dependent long-term memory formation.